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DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes via three nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic illness syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated how https://deanokdxp.collectblogs.com/73648481/the-single-best-strategy-to-use-for-register-here

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