There's a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to minimize afferent pain transmission and produce analgesia. Therefore, drugs like clonidine that concentrate on alpha-2 receptors can impact the transmission of discomfort. Applies to clonidine: oral pill, oral https://omarv848afg8.national-wiki.com/user