Epidural clonidine applied as an adjunct to nearby anesthetics has three different mechanisms of action. Initially, the stimulation of alpha-two-receptors in the dorsal horn decreases discomfort transmission. Secondly, clonidine could cause area vasoconstriction that limits vascular removal of local epidural anesthetics. Clonidine treats high hypertension by stimulating αtwo receptors https://alicer713fie7.law-wiki.com/user