Interactions with Benzodiazepines and Other CNS Depressants Advise patients and caregivers that potentially lethal additive effects could take place if acetaminophen and codeine phosphate tablets are used with benzodiazepines or other CNS depressants, such as alcohol, and never to use these drugs concomitantly Except supervised by a healthcare provider (see https://britedirectory.com/listings13181804/promethazine-with-codeine-doses-for-adults-an-overview