Antibiotic resistance is a major public health concern. The shrinking selection of effective antibiotics and lack of new development is making the situation worse. Gram-negative bacteria more specifically pose serious threat because of their double layered cell envelope and effective efflux systems. which is a challenge for drugs to penetrate. https://www.roneverhart.com/Castello-di-Amorosa-Il-Barone-Napa-Valley-Cabernet-Sauvignon-2007/